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Granulocyte Colony Stimulating Factor

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Granulocyte Colony Stimulating Factor, G-CSF

  • See Also
  1. Filgrastim
  2. Pegfilgrastim
  3. Sargramostim
  • Indications
  1. Chemotherapy-Induced Neutropenia
  2. Neutropenia Prophylaxis with Chemotherapy initiation
    1. Febrile Neutropenia risk >=20%
    2. History of neutropenic complications with prior treatments
  3. Neutropenia with recurrent severe infections (e.g. Periodontal Disease, Cellulitis, Pneumonia, abscess)
  • Contraindications
  1. Acute Leukemia
  2. Myelodysplastic Syndrome
  • Mechanism
  1. Granulocyte Colony-Stimulating Factor (G-CSF) is an endogenous Cytokine
    1. Modulates the production, differentiation and function Neutrophilic Granulocyte progenitors
  2. G-CSF is endogenously produced by Monocytes, fibroblasts, and endothelial cells
  3. G-CSF activates Granulocyte production via binding specific cell surface receptors
  • Medications
  1. See Granulocyte Macrophage Colony-Stimulating Factor (e.g. Sargramostim)
  2. Filgrastim (Neupogen, Granix, Zarxio)
  3. Pegfilgrastim (Neulasta, Fulphilia, Udenyca)
  • Adverse Effects
  1. Serious
    1. Longterm malignancy risk (esp. in Severe Congenital Neutropenia)
  2. Common
    1. Bone pain
    2. Arthralgias
    3. Myalgias
    4. Headache
  • References
  1. Cetean (2015) Clujul Med 88(4):468-72 +PMID: 26732055 [PubMed]
  2. Kim (2025) Am Fam Physician 112(6): 618-28 [PubMed]